Klei have been working on improving Mark of the Ninja: Remastered with a recent beta that's now live for everyone. Two Linux-specific issues were found and fixed.
Released back in October, Mark of the Ninja: Remastered bundled the DLC of the original game along with some graphical enhancements, much improved gamepad support for Linux gamers along with much better multi-monitor handling on Linux too. I wasn't honestly expecting it to be improved as much as it has.
The trouble is, the game was practically broken for AMD GPU users. Not any more! Klei put out a patch yesterday which should fix the problems along with a crash when shutting the game down on Linux. Another Linux-specific fix, was some kind of interference from motion sensors in the PS4 controller which should no longer happen.
Not stopping there, the patch also includes some performance improvements so you should see less hitching and stuttering during gameplay as it will now save games asynchronously. The mouse cursor should also be hidden when using a gamepad, along with multiple other fixes. See the full list here.
It's currently only available on Steam and I think it's well worth it, excellent game.