If you make use of the Wine compatibility layer on Fedora, it seems the upcoming Fedora 33 release may end up defaulting to DXVK for better performance.
Currently in Fedora, like most distributions, Wine is mostly left alone. Once installed, it's up to users to tinker with it and configure it (I much prefer using Lutris personally). That may change though if this latest proposal is accepted for Fedora 33 which releases in October 2020. There is currently a dedicated wine-dxvk package you can install to get it but this change would set DXVK as the default graphics backend for Wine to translate Direct3D 9/10/11 to Vulkan.
The benefits are obvious, like giving users of Wine a much better gaming experience for Windows-only titles. DXVK is used in Proton for Steam Play, it's developed at a quick pace for game compatibility and the performance is often far better than Wine's own wined3d which translates Direct3D to OpenGL.
See the proposal here if interested.