Introducing Faster Than Light a game that is coming for Linux, Mac and Windows and it's, err, hard to describe really - they describe it as a Spaceship Simulation Real-Time Rouge-Like (now that's a Genre!).
They have a Kickstarter going right now to gather funds currently at $32,000+ where it openly lists Linux and their latest update tells of it too, so you can call it confirmed!
They have said they will be looking at Desura as one of their main channels of selling especially since it is equipped for Alpha funding games.
It looks very cool!